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Isolation and Primary Culture of Rat Hepatic Cells
Published on: June 29, 2012
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Surgical therapy of primary hepatic angiosarcoma
Verena Tripke1, Stefan Heinrich1, Tobias Huber1
1Department of General, Visceral and Transplantation Surgery, University Hospital of Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany.
BMC Surgery
|January 12, 2019
Summary
Radical surgical resection offers the best chance for long-term survival in patients with primary hepatic angiosarcoma (PHA). Complete tumor removal through surgery is crucial for improving outcomes in this rare liver cancer.
Area of Science:
- Hepatobiliary surgery
- Surgical oncology
- Rare tumors
Background:
- Primary hepatic angiosarcoma (PHA) is an exceptionally rare liver malignancy.
- Radical surgical resection is the current standard of care for PHA.
- This study evaluates surgical outcomes for PHA.
Purpose of the Study:
- To report the institutional experience with surgical resection of primary hepatic angiosarcoma.
- To analyze survival rates and recurrence patterns following PHA resection.
- To assess the efficacy of surgical intervention for PHA.
Main Methods:
- A retrospective analysis of patients undergoing PHA resection from 2002 to 2017.
- Confirmation of PHA diagnosis by a second pathologist.
- Evaluation of resection completeness, overall survival (OS), and disease-free survival (DFS).
Main Results:
- Nine patients with PHA underwent hepatic resection.
- Median follow-up was 15.5 months; 4/9 patients survived.
- Complete resection (R-0) in 8 patients correlated with improved median OS (59 months) and DFS (11 months).
Conclusions:
- Surgical resection is the only curative option for primary hepatic angiosarcoma.
- Complete tumor removal offers a chance for long-term survival.
- Surgical evaluation should be considered for all PHA cases.
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