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Classical Hodgkin's Lymphoma with Skeletal Muscle Involvement: A Testing Case
Syed Ali Shazif Baqari1, Mairah Razi2, Javeria Hayat3
1Department of Pediatric Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|January 12, 2019
Summary
Skeletal muscle involvement in Hodgkin lymphoma is rare. This case report details successful treatment of a child with stage IV disease and muscle involvement using chemotherapy and stem cell rescue.
Area of Science:
- Oncology
- Pediatric Hematology-Oncology
- Rare Cancer Presentations
Background:
- Hodgkin lymphoma (HL) rarely involves skeletal muscle.
- Stage IV Hodgkin lymphoma presents a significant treatment challenge, especially with extranodal involvement.
Observation:
- An 11-year-old male presented with stage IV Hodgkin lymphoma and extensive skeletal muscle involvement in the gluteal, piriformis, and psoas muscles.
- The patient's disease was refractory to initial treatments.
Findings:
- The patient achieved remission with third-line chemotherapy (EPIC) followed by high-dose chemotherapy and autologous stem cell rescue.
- Positron emission tomography/computed tomography (PET/CT) scans were crucial for evaluating treatment response.
Implications:
- This case highlights the importance of multidisciplinary team collaboration in managing rare presentations of Hodgkin lymphoma.
- Successful treatment of refractory, advanced Hodgkin lymphoma with skeletal muscle involvement demonstrates the efficacy of modern therapeutic strategies.
- Early and accurate diagnosis and tailored treatment plans are vital for improving outcomes in pediatric oncology.