Related Experiment Video
Updated: Jan 30, 2026
06:04
Author Spotlight: Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model
Published on: June 9, 2023
1.5K
Emergence of preconfigured and plastic time-compressed sequences in early postnatal development
1Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA.
Science (New York, N.Y.)
|January 12, 2019
Summary
The developing brain gradually organizes hippocampal neuronal networks for memory. Experience-independent sequences form by week 3, with adult-like memory processing emerging by week 4.
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Cognitive Neuroscience
Background:
- The organization of hippocampal neuronal ensembles is crucial for episodic memory.
- The developmental timeline and mechanisms underlying this organization remain largely unknown.
Purpose of the Study:
- To investigate the emergence of hippocampal neuronal ensemble organization supporting memory encoding and consolidation.
- To determine the roles of age, navigational experience, and sleep in this developmental process.
Main Methods:
- Electrophysiological recordings from large hippocampal neuronal ensembles in naïve rats.
- Recordings were conducted from eye opening through postnatal week 4 during navigation and sleep in linear environments.
Main Results:
- Preconfigured, trajectory-like sequences assembled independently of navigational experience by postnatal week 3.
- Adult-like compressed trajectory formation during navigation and experience-dependent replay during sleep emerged concurrently in early postnatal week 4.
- These sequential patterns developed from spontaneous, preconfigured sequences.
Conclusions:
- Distinct developmental phases exist for hippocampal sequential pattern formation.
- Early development involves experience-independent preconfiguration, followed by experience-dependent refinement crucial for episodic memory.
Related Concept Videos
01:27Emerging Adulthood
681
Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
681
00:58Plasticity
3.1K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
3.1K
01:31Plasticizers
367
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
367
01:21Plastic Behavior
573
A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
573
01:14Plastic Deformations
438
It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
438
01:19Plastic Deformations
461
Plastic deformation represents a fundamental concept in materials science, which explains the irreversible change in the shape of a material when it experiences stress beyond its elastic capability. This phenomenon is important in structural engineering, especially in designing and analyzing cantilever beams—structures that are securely fixed at one end and bear loads at the opposite end. When these beams are subjected to loads within their elastic range, they will return to their...
461