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Synthesis of cyano-substituted carbazoles via successive C-C/C-H cleavage
Yajie Yang1, Jiaqi Huang, Hailu Tan
1Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. yzli@chem.ecnu.edu.cn.
Abstract:
A highly efficient protocol for the synthesis of polysubstituted cyano carbazoles has been developed. This process is realized through the tandem reactions of Cs2CO3 promoted C-C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C-H and/or C-C bond activations. Two of the sp2 C-H bonds are functionalized, and two of the C-C σ-bonds are cleaved involving a 1,2-acyl migration during the reaction process.
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