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Related Concept Videos

Plasticity00:58

Plasticity

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Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
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Plasticizers01:31

Plasticizers

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Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
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Plastic Behavior01:21

Plastic Behavior

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A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
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Plastic Deformations01:14

Plastic Deformations

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It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
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Plastic Deformations01:19

Plastic Deformations

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Plastic deformation represents a fundamental concept in materials science, which explains the irreversible change in the shape of a material when it experiences stress beyond its elastic capability. This phenomenon is important in structural engineering, especially in designing and analyzing cantilever beams—structures that are securely fixed at one end and bear loads at the opposite end. When these beams are subjected to loads within their elastic range, they will return to their...
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Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Related Experiment Video

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Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells
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Plastic-based acoustofluidic devices for high-throughput, biocompatible platelet separation.

Yuyang Gu1, Chuyi Chen, Zeyu Wang

  • 1Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27707, USA. tony.huang@duke.edu.

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Summary
This summary is machine-generated.

This study introduces a disposable plastic acoustofluidic device for high-throughput platelet separation using sound waves, offering a promising alternative for blood donation and essential thrombocytosis treatment.

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Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Cell Separation Technologies

Background:

  • Platelet separation is vital for blood donation and treating essential thrombocytosis.
  • Current methods can be complex and may impact platelet quality.

Purpose of the Study:

  • To develop a high-throughput, biocompatible, and disposable device for platelet separation.
  • To utilize acoustofluidics for efficient cell separation.

Main Methods:

  • An acoustofluidic device made entirely of plastic was fabricated.
  • The device processed undiluted human whole blood using sound waves.
  • Performance metrics including throughput, recovery, and removal rates were evaluated.

Main Results:

  • Achieved a sample throughput of 20 mL/min.
  • Demonstrated a platelet recovery rate of 87.3% and red/white blood cell removal rate of 88.9%.
  • Isolated platelets showed preserved function and integrity compared to established methods.

Conclusions:

  • The disposable plastic acoustofluidic device offers rapid fabrication and high throughput.
  • It provides a biocompatible and promising alternative to existing platelet separation techniques.