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Author Spotlight: Advancing 3D Coculture Systems with PVA-PCL Nanofibrous Membranes
Published on: December 27, 2024
Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk
R Mukherjee1, M van de Kaa, J Garssen
1Division of Chemical Biology and Drug Discovery, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, The Netherlands. r.mukherjee@uu.nl reshmi.mukherjee@gmail.com.
Abstract:
Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.
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