Related Experiment Video
Updated: Jan 30, 2026
12:16
A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
Published on: October 16, 2018
15.5K
CAR-T cells beyond CD19, UnCAR-Ted territory
Mark B Leick1,2, Marcela V Maus1,2
1Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, Massachusetts.
American Journal of Hematology
|January 12, 2019
Summary
Chimeric antigen receptor T-cell (CAR-T) therapy shows promise beyond CD19 targets in blood cancers. This review explores CAR-T applications in Hodgkin
Area of Science:
- Oncology
- Immunotherapy
- Hematology
Background:
- Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized B-cell malignancies treatment.
- CD19-targeted CAR-T cells demonstrate significant efficacy in B-cell cancers.
Purpose of the Study:
- To review the expanding applications of CAR-T cells in hematologic malignancies.
- To focus on CAR-T cell efficacy beyond CD19 targets, specifically in Hodgkin's lymphoma and acute myeloid leukemia.
Main Methods:
- Literature review of preclinical and clinical studies on CAR-T cell therapy.
- Analysis of CAR-T cell targets and efficacy in various hematologic cancers.
- Examination of challenges and future directions for non-CD19 CAR-T applications.
Main Results:
- CAR-T cell therapy is being investigated for targets beyond CD19 in hematologic cancers.
- Emerging data suggests potential for CAR-T cells in Hodgkin's lymphoma and acute myeloid leukemia.
- Non-CD19 CAR-T strategies are under development to overcome resistance and expand therapeutic options.
Conclusions:
- CAR-T cell therapy holds potential for treating hematologic malignancies beyond CD19-positive B-cell cancers.
- Further research is needed to optimize non-CD19 CAR-T cell therapies for Hodgkin's lymphoma and acute myeloid leukemia.
- Expanding CAR-T targets is crucial for improving outcomes in refractory hematologic malignancies.
Related Concept Videos
02:34Competition
24.7K
When organisms require the same limited resources within an environment, they may have to compete for them. Competition is a net-negative interaction. Even if two competing individuals or populations do not interact directly, the overall fitness of both competitors is lowered as a result of not having full access to the limited resource.
24.7K
01:07What are Cells?
199.2K
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
199.2K
02:35Chromatin Position Affects Gene Expression
24.8K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area.
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.8K
02:03What is Cell Signaling?
130.3K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
130.3K
02:41Concentration Cells
25.9K
A concentration cell is a type of a voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
Consider the following voltaic cell:
Consider the following voltaic cell:
25.9K
02:58Chemistry of the Cell
47.9K
The cell is chemically composed of water, organic molecules and inorganic ions.
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
47.9K