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Cardiac Findings in Fetal and Pediatric Autopsies: A 15-Year Retrospective Review

Mana Taweevisit1, Paul Thorner1,2

  • 1a Pathology, Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.

Fetal and Pediatric Pathology
|January 12, 2019
PubMed

Insights

Autopsies reveal a wide spectrum of congenital heart defects (CHDs) in pediatric patients. Postmortem examination is crucial for accurate diagnosis and genetic counseling.

Area of Science:

  • Pediatric Pathology
  • Cardiovascular Research
  • Medical Genetics

Background:

  • Congenital heart defects (CHDs) are a leading cause of morbidity and mortality in children.
  • Understanding the spectrum of CHDs is vital for improving patient outcomes.
  • Autopsy remains a critical tool for diagnosing CHDs and associated anomalies.

Purpose of the Study:

  • To determine the spectrum of congenital heart defects (CHDs) using fetal and pediatric autopsies.
  • To correlate autopsy findings with prenatal echocardiography.
  • To assess the diagnostic accuracy of prenatal imaging for CHDs.

Main Methods:

  • Retrospective review of 608 autopsy reports over 15 years.
  • Correlation of postmortem findings with echocardiography records.
  • Analysis of extracardiac malformations and chromosomal abnormalities in CHD cases.

Main Results:

  • 119 cases (19.6%) had congenital heart defects (CHDs).
  • Persistent left superior vena cava was the most common defect; 41% had extracardiac malformations, and 18.5% had chromosomal abnormalities.
  • Prenatal echocardiography showed 85% correlation with autopsy findings, missing milder defects.

Conclusions:

  • Postmortem examination is essential for precise CHD anatomy delineation.
  • Autopsies aid in identifying extracardiac malformations and potential genetic syndromes.
  • Findings support accurate parental counseling and evaluation of prenatal imaging accuracy.
Abstract

Keywords:
autopsycongenital heart defectsfetalpediatric

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