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The cortical dementias
1Neuropsychiatric Unit, Royal Ottawa Hospital, Ontario.
Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
|December 1, 1988
Summary
New technologies offer insights into primary dementias like Alzheimer's disease. Locating the Alzheimer's gene on chromosome 21 advances diagnosis and potential treatments.
Area of Science:
- Neurology
- Genetics
- Molecular Biology
Background:
- Primary dementias, including Alzheimer's disease and Pick's disease, represent significant neurological challenges.
- Recent advancements in technology and research are providing novel perspectives on these conditions.
Purpose of the Study:
- To review and synthesize existing and emerging data on cortical dementias.
- To highlight the significance of genetic discoveries in understanding Alzheimer's disease.
Main Methods:
- Review of current literature on primary dementias.
- Analysis of genetic research, specifically focusing on Alzheimer's disease.
Main Results:
- Identification of the gene responsible for familial Alzheimer's disease on chromosome 21.
- The study of the amyloid protein precursor gene shows promise for diagnostic and therapeutic advancements.
Conclusions:
- Genetic research, particularly the identification of the Alzheimer's gene, is crucial for understanding and potentially treating the disease.
- Continued research into the amyloid protein precursor gene may lead to breakthroughs in laboratory diagnosis and treatment of Alzheimer's disease.