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Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue

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Published on: February 11, 2013

Clearing the Fog surrounding Chemobrain.

David H Gutmann¹

¹Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

|January 12, 2019

Summary

Chemotherapy can cause long-term cognitive deficits in cancer survivors. A new study shows that microglia, immune cells in the brain, orchestrate these chemotherapy-related cognitive impairments.

Area of Science:

Neuroscience
Oncology
Immunology

Background:

Increasing number of cancer survivors due to successful chemotherapy.
Long-term sequelae of cancer treatment include cognitive deficits impacting daily function.

Purpose of the Study:

To investigate the role of microglia in chemotherapy-related cognitive impairment.

Main Methods:

The study by Gibson et al. (2019) in Cell utilized experimental models to examine the mechanisms underlying chemotherapy-induced cognitive dysfunction.

Main Results:

Chemotherapy-related cognitive impairment is orchestrated by microglia.
Microglia play a central role in mediating the cognitive deficits associated with chemotherapy.

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Conclusions:

Microglia are key players in the development of chemotherapy-related cognitive impairment.
Understanding the role of microglia may lead to strategies for mitigating cognitive side effects in cancer survivors.