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Updated: Jan 30, 2026

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
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[Effect of Chinese Drugs for Breaking Blood Expelling Stasis on Acute Cerebral Hemorrhage: a Prospective Randomized

Zhang-Yong Xia, Jing Wang, Jian-Wen Guo

    Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine
    |January 12, 2019
    PubMed

    Insights

    Chinese drugs for breaking blood expelling stasis (CDBBES) did not increase hematoma enlargement in patients with intracerebral hemorrhage. This study found no significant difference in hematoma enlargement rates among treatment and placebo groups.

    Area of Science:

    • Neurology
    • Pharmacology
    • Traditional Chinese Medicine

    Background:

    • Intracerebral hemorrhage (ICH) is a critical condition often managed with interventions to control bleeding.
    • Chinese drugs for breaking blood expelling stasis (CDBBES) are used in traditional medicine, but their safety in acute ICH requires rigorous evaluation.

    Purpose of the Study:

    • To assess the safety of CDBBES in patients with ICH within 6 hours of onset.
    • To determine if CDBBES contributes to hematoma enlargement in this patient population.

    Main Methods:

    • A prospective, randomized, double-blind, placebo-controlled study involving 76 ICH patients within 6 hours of symptom onset.
    • Patients were assigned to receive either whole CDBBES, CDBBES without specific components, or placebo for 10 days.
    • Outcomes measured included hematoma enlargement rate within 24 hours and adverse events.

    Main Results:

    • The hematoma enlargement rates were 11.5% (Group A), 16.0% (Group B), and 20.0% (Group C), with no statistically significant differences between groups (P = 0.682).
    • Adverse events were reported in 7 patients, including acute myocardial infarction and diarrhea, primarily in the group receiving whole CDBBES.

    Conclusions:

    • Interim analysis indicates that CDBBES does not cause hematoma enlargement in patients with intracerebral hemorrhage treated within 6 hours of onset.
    • Further research may be warranted to fully elucidate the safety profile and efficacy of CDBBES in ICH management.
    Abstract

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