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Candida sp. Infections in Patients with Diabetes Mellitus

Célia F Rodrigues1,2, Maria Elisa Rodrigues3, Mariana Henriques4

  • 1CEB, Centre of Biological Engineering, LIBRO-Laboratório de Investigação em Biofilmes Rosário Oliveira, University of Minho, 4710-057 Braga, Portugal. c.fortunae@gmail.com.

Journal of Clinical Medicine
|January 13, 2019
PubMed

Insights

Diabetes mellitus (DM) patients face higher risks of candidiasis due to impaired immunity. Uncontrolled blood sugar and medical devices worsen these fungal infections, increasing hospital stays and costs.

Area of Science:

  • Medical Mycology
  • Endocrinology
  • Infectious Diseases

Background:

  • Candidiasis incidence is rising globally, posing significant risks, particularly for critically ill patients.
  • Diabetes mellitus (DM) compromises the immune system, increasing susceptibility to fungal infections like candidiasis.
  • Understanding the interplay between DM and Candida infections is crucial for patient management.

Purpose of the Study:

  • To review recent studies on candidiasis occurrence in patients with diabetes mellitus.
  • To explore the pathophysiology and etiology linking these two conditions.
  • To highlight the impact of co-morbidities on infection outcomes.

Main Methods:

  • A comprehensive literature review was conducted.
  • Searches were performed across major scientific databases: PubMed, Scopus, ScienceDirect, and SpringerLink.
  • Inclusion and exclusion criteria were applied to select relevant studies.

Main Results:

  • Diabetes mellitus patients exhibit heightened susceptibility to Candida sp. infections.
  • Hyperglycemia significantly exacerbates the severity and frequency of candidiasis in diabetic individuals.
  • Increased hospitalization and prolonged use of indwelling medical devices are common in these patients.

Conclusions:

  • Diabetic patients are at a greater risk for candidiasis, especially with poor glycemic control.
  • The management of candidiasis in DM patients is complex, often requiring longer hospital stays.
  • Associated factors like indwelling devices contribute to increased healthcare costs for managing these infections.
Keywords:
Candidabiofilmscandidiasisdiabeteshyperglycemiainfectionmedical devicesmetabolic disorder

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