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MS-Helios: a Circos wrapper to visualize multi-omic datasets.

Harald Marx1,2, Joshua J Coon3,4,5,6

  • 1Department of Microbiology and Ecosystems Science, University of Vienna, 1090, Vienna, Austria. harald.marx@wisc.edu.

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Summary
This summary is machine-generated.

MS-Helios simplifies multi-omic data visualization by enabling non-experts to create circular plots. This tool facilitates the mapping and comprehensive analysis of complex biological datasets.

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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Computational Biology

Background:

  • High-resolution mass spectrometry generates vast amounts of multi-omic data, including metabolites and proteins.
  • Analyzing and visualizing this complex data requires advanced methods for dimensionality reduction and compact representation.
  • Current methods for creating circular proteome maps (CPMs) demand significant data preprocessing and expertise with tools like Circos.

Purpose of the Study:

  • To develop an accessible software tool for constructing circular plots from multi-omic data.
  • To enable non-expert users to generate high-quality visualizations without extensive prior data transformation or specialized knowledge.
  • To facilitate the holistic visualization and contextualization of large-scale multi-omic datasets.

Main Methods:

  • Introduction of MS-Helios, a command-line tool with integrated data processing functions.
  • Automated generation of data and configuration files for creating circular plots using Circos.
  • Demonstration of MS-Helios on large-scale multi-omic datasets.

Main Results:

  • MS-Helios allows non-expert users to easily construct circular plots (CPMs) with a non-genomic basis.
  • The tool automatically prepares data and configuration files for high-quality, publishable circular plots.
  • MS-Helios effectively visualizes global trends and contextualizes specific features within multi-omic datasets.

Conclusions:

  • MS-Helios offers a user-friendly solution for mapping and visualizing multi-omic data.
  • The software enhances the comprehensive analysis of complex biological datasets.
  • MS-Helios, associated datasets, source code, and tutorials are publicly available for broader accessibility.