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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Polymorphisms in IL36G gene are associated with plaque psoriasis
Tanel Traks1, Maris Keermann2,3, Ele Prans4
1Department of Dermatology and Venerology, University of Tartu, 31 Raja St, 50417, Tartu, Estonia. tanel.traks@ut.ee.
BMC Medical Genetics
|January 13, 2019
Summary
Genetic variations in the IL36G gene are linked to plaque psoriasis. Specific single nucleotide polymorphisms (SNPs) and haplotypes show significant associations, suggesting IL-36γ
Area of Science:
- Immunodermatology
- Human Genetics
- Molecular Biology
Background:
- Plaque psoriasis involves immune dysregulation, with cytokines like IL-36 family members playing a role.
- While IL36RN has been studied, IL36G's role in plaque psoriasis is less understood.
- Elevated IL36G levels and its link to the IL-23/IL-17 axis highlight its potential significance.
Purpose of the Study:
- To investigate the association between genetic variations in the IL36G gene and plaque psoriasis.
- To identify specific single nucleotide polymorphisms (SNPs) and haplotypes within IL36G associated with the disease.
Main Methods:
- Genotyping of eleven SNPs in the IL36G region was performed in 728 plaque psoriasis patients and 320 healthy controls.
- Association tests were conducted for allele and haplotype frequencies.
- Subgroup analyses were performed based on clinical characteristics like sex, age of onset, and disease severity (BSA, PASI).
Main Results:
- Three SNPs (rs28947206, rs28947207, rs28947211) showed significant association with plaque psoriasis (padj < 0.0054).
- These SNPs, along with rs28947205 and rs12328178, formed haplotype blocks.
- Two haplotypes, CAGC and TGTT, demonstrated significant associations with plaque psoriasis (padj < 0.0462).
Conclusions:
- The study confirms a genetic association between IL36G variants and plaque psoriasis development.
- Associated SNPs may influence IL-36γ cytokine function, potentially impacting disease pathology.
- Further research is needed to elucidate the precise mechanisms and causal effects of these genetic variants.
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