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Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
Published on: February 9, 2024
[Implementation of National Cervical Cancer Screening Program in France]
Anne-Sophie Woronoff1, Florence Molinié2, Brigitte Trétarre3
1CHRU Besançon, Registre des tumeurs du Doubs et du Territoire de Belfort, 3, boulevard Fleming, 25030 Besançon cedex, France; Université de Franche-Comté, EA3181, 19, rue Ambroise-Paré, 25000 Besançon, France; Réseau français des registres de cancers (Francim), 37, allées Jules-Guesde, 31073 Toulouse, France.
Abstract:
In 2017 in France, cervical cancer (CC) was diagnosed in 2850 women and 1100 women died. The decline in incidence and mortality rates observed for several decades has slowed since the early 2000s. CC is due to the persistence of a sexually transmitted infection by human papillomaviruses (HPV). Currently CC prevention depends on HPV vaccination and Pap smear tests (PST) and up until 2018 diagnosis has been carried out an individual basis in France. The 2014-2019 French Cancer Plan has planned to implement a nationally organized screening program of CC which proposes in the short term to continue screening by PST, according to the recommendations set by HAS in 2010, while creating the conditions for the transition to HPV-testing in primary screening. The objective of this program is to reduce the incidence and number of CC deaths by 30% within the next 10 years, by achieving an 80% coverage rate in the target population and making screening more accessible to vulnerable populations and/or those who have poor access to the healthcare system. CC is one of the rare cancers that could become exceptional. The combination of the two primary and secondary prevention methods, with high rates of vaccination and screening coverage, should make it possible to eliminate this cancer in countries with sufficient economic resources for the effective implementation of these prevention programs.
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