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Related Experiment Video

Updated: Jan 30, 2026

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

MRI Quantitative T2* Mapping to Predict Dominant Composition of In Vitro Thrombus.

R Bourcier¹, R Pautre², M Mirza³

¹From the Departments of Neuroradiology (R.B., R.P., L.D., H.D.) romain.bourcier2@gmail.com romain.bourcier@chu-nantes.

AJNR. American Journal of Neuroradiology

|January 13, 2019

Summary

Quantitative T2* mapping using MR imaging reliably identifies red blood cell content in vitro thrombi. This technique can help predict stroke etiology and guide endovascular treatment strategies for acute ischemic stroke.

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Area of Science:

Biomedical Imaging
Radiology
Stroke Research

Background:

Acute ischemic stroke treatment relies on rapid assessment of thrombus characteristics.
Magnetic Resonance (MR) imaging quantitative T2* mapping offers insights into thrombus composition, particularly red blood cell (RBC) content.
Pre-treatment thrombus characterization may optimize endovascular strategies.

Purpose of the Study:

To analyze the relationship between red blood cell content in in vitro thrombi and their T2* relaxation times.
To evaluate the potential of MR imaging quantitative T2* mapping for assessing thrombus composition before acute ischemic stroke treatment.

Main Methods:

Thirty-five in vitro thrombus analogs with varying compositions were scanned using MR imaging quantitative T2* mapping.
Thrombus T2* relaxation times were measured twice by two blinded radiologists to assess reproducibility.
Quantitative histological analysis determined red blood cell content.
Intraclass correlation coefficients assessed inter- and intraobserver reproducibility.
Spearman correlation analyzed the relationship between T2* relaxation time and RBC content.

Main Results:

The median thrombus T2* relaxation time was 78.5 ms (IQR, 60.5 ms).
The median red blood cell content was 55% (IQR, 75%).
Excellent inter- and intraobserver reproducibility for T2* measurements was observed (ICC > 0.9).
A significant inverse correlation was found between thrombus T2* relaxation time and red blood cell content (ρ = -0.834, P < .001).

Conclusions:

MR imaging quantitative T2* mapping reliably determines in vitro thrombus red blood cell content.
This rapid and user-friendly MR sequence shows potential for routine clinical use.
It may aid in predicting stroke etiology and tailoring endovascular treatment approaches for acute ischemic stroke.