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Crosstalk between metabolism and circadian clocks
Hans Reinke1,2, Gad Asher3
1University of Düsseldorf, Medical Faculty, Institute of Clinical Chemistry and Laboratory Diagnostics, Düsseldorf, Germany. hans.reinke@med.uni-duesseldorf.de.
Nature Reviews. Molecular Cell Biology
|January 13, 2019
Summary
The body
Area of Science:
- Chronobiology
- Metabolic regulation
- Physiology
Background:
- Mammalian daily behavior is divided into activity and rest phases with distinct metabolic needs.
- The circadian clock synchronizes behavior with the solar day, coordinating metabolic programs.
- A master brain clock, synchronized by light, controls organism-wide circadian rhythms.
Purpose of the Study:
- To explore the intricate connection between the circadian clock and metabolic regulation.
- To understand how cellular oscillators coordinate metabolic processes.
- To investigate the feedback mechanisms between metabolism and circadian rhythms.
Main Methods:
- Review of existing literature on circadian biology and metabolism.
- Analysis of molecular and systemic mechanisms linking circadian clocks and metabolism.
- Examination of the role of nutrient, energy, and redox levels in circadian regulation.
Main Results:
- Circadian clocks in individual cells control metabolic programs, conferring rhythmicity to organs.
- Metabolic status influences cellular clocks, reinforcing rhythmicity and adapting physiology.
- A complex crosstalk exists between circadian systems and metabolism at all biological levels.
Conclusions:
- The circadian clock and metabolism are deeply interconnected through multiple feedback loops.
- Disruptions in this circadian-metabolic crosstalk are linked to various pathologies.
- Understanding this relationship is crucial for metabolic health and disease prevention.
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