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Related Concept Videos

Nucleic Acids02:43

Nucleic Acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic acids02:43

Nucleic acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic Acids02:43

Nucleic Acids

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Nucleic Acid Structure01:25

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
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Nucleic Acids and Nucleotides01:20

Nucleic Acids and Nucleotides

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
Deoxyribonucleic Acid (DNA)
DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria....
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Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

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Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
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Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
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Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

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Nucleic Acid Therapies for Ischemic Stroke.

Nils Henninger1,2, Yunis Mayasi3

  • 1Department of Neurology, University of Massachusetts Medical School, 55 Lake Ave, North, Worcester, MA, 01655, USA. nils.henninger@umassmed.edu.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|January 13, 2019
PubMed
Summary
This summary is machine-generated.

Nucleic acid therapeutics offer new avenues for stroke prevention and treatment. These advanced therapies, including aptamers and antisense oligonucleotides, show promise in managing stroke causes and aiding recovery.

Keywords:
NeuroprotectionNucleic acidPreventionReviewStrokeTherapy

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Area of Science:

  • Neurology
  • Biotechnology
  • Genetics

Background:

  • Stroke is a major global cause of death and disability.
  • Current stroke treatments require improvement for better patient outcomes.
  • Novel therapeutic strategies are essential for stroke care.

Purpose of the Study:

  • To review the application of nucleic acid therapeutics in stroke care.
  • To explore how these therapies can enhance stroke prevention, acute treatment, and recovery.
  • To highlight the potential of aptamers, antisense oligonucleotides, and microRNAs in managing stroke.

Main Methods:

  • Review of current literature on nucleic acid therapeutics for stroke.
  • Analysis of aptamer systems for antithrombotic and thrombolytic therapy.
  • Examination of antisense oligonucleotide therapy for genetic stroke causes like elevated lipoprotein (a) and CADASIL.
  • Investigation of microRNA targeting for neuroprotection and neuroregeneration.

Main Results:

  • Aptamer systems are being developed to improve antithrombotic and thrombolytic treatments.
  • Antisense oligonucleotide therapy shows potential for genetically determined stroke causes.
  • MicroRNA targeting offers a strategy to modulate neuronal cell death and promote neurorestoration.
  • MicroRNAs may assist in classifying stroke subtypes for effective secondary prevention.

Conclusions:

  • Nucleic acid therapeutics represent a promising frontier in improving stroke prevention and treatment.
  • Targeting genetic factors and regulatory pathways with nucleic acids can address unmet needs in stroke care.
  • Further research into aptamers, antisense oligonucleotides, and microRNAs is crucial for advancing stroke medicine.