Related Experiment Video
Updated: Jan 30, 2026
08:22
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
5.2K
Anterior segment optical coherence tomography and its clinical applications
Sarah B Wang1, Elisa E Cornish1,2,3, John R Grigg1
1Faculty of Medicine and Health, Save Sight Institute, The University of Sydney, Sydney Eye Hospital, Sydney, New South Wales, Australia.
Clinical & Experimental Optometry
|January 13, 2019
Summary
Anterior segment optical coherence tomography (AS-OCT) is a key non-contact imaging tool for eye structures. This review highlights its diagnostic, therapeutic, and prognostic utility but notes a lack of high-level evidence, calling for more RCTs.
Area of Science:
- Ophthalmology
- Medical Imaging
- Biomedical Engineering
Background:
- Anterior segment optical coherence tomography (AS-OCT) is a crucial non-contact imaging technique.
- It assesses ocular structures like the cornea, anterior chamber angle, and ocular surface.
- AS-OCT has diverse clinical applications documented in scientific literature.
Purpose of the Study:
- To review the existing literature on the clinical utility and efficacy of AS-OCT.
- To evaluate the quality of evidence supporting AS-OCT applications.
- To identify areas for future research and validation of AS-OCT technology.
Main Methods:
- A comprehensive literature search was conducted across multiple databases (Medline, Cochrane, PubMed, etc.) up to June 24, 2018.
- Inclusion criteria focused on studies using OCT for anterior segment visualization.
- Study selection, data extraction, and risk of bias assessment were performed following PRISMA guidelines.
Main Results:
- The review included 82 studies encompassing various designs (cohort, case series, observational).
- Primary outcomes measured included anterior chamber dimensions, corneal thickness, tear meniscus parameters, and AS structure morphology.
- Evidence for AS-OCT in diagnostics, therapeutics, and prognostics was reviewed, revealing a breadth of applications.
Conclusions:
- AS-OCT is a valuable tool with broad clinical applications in ophthalmology.
- There is a significant lack of high-level evidence (e.g., RCTs, meta-analyses) supporting its use.
- Future research should focus on generating high-quality evidence to further validate AS-OCT technology.
Related Concept Videos
01:19Clinical Applications of Epidermal Stem Cells
3.3K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K
01:11Local Anesthetics: Clinical Application as Spinal Anesthesia
1.4K
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
1.4K
01:29Local Anesthetics: Clinical Application as Epidural Anesthesia
735
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
735
01:16Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
1.3K
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
One of the advantages of...
1.3K
01:26Muscles of the Anterior Neck
4.7K
The anterior neck muscles are the group of muscles covering the front part of the neck. These muscles are classified into three subgroups. The first one is the superficial muscles, the most visible muscles in the front of the neck. It includes the platysma and sternocleidomastoid. The second group is the suprahyoid muscles, located above the hyoid bone. This group comprises the digastric, mylohyoid, geniohyoid, and stylohyoid. Lastly, the infrahyoid muscles are found below the hyoid bone and...
4.7K
01:30Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
2.0K
Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
2.0K