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Updated: Jan 30, 2026

Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures
Published on: December 1, 2020
Structure Retrieval at Atomic Resolution in the Presence of Multiple Scattering of the Electron Probe
H G Brown1, Z Chen1, M Weyland2,3
1School of Physics and Astronomy, Monash University, Victoria 3800, Australia.
Abstract:
The projected electrostatic potential of a thick crystal is reconstructed at atomic resolution from experimental scanning transmission electron microscopy data recorded using a new generation fast-readout electron camera. This practical and deterministic inversion of the equations encapsulating multiple scattering that were written down by Bethe in 1928 removes the restriction of established methods to ultrathin (≲50 Å) samples. Instruments already coming on line can overcome the remaining resolution-limiting effects in this method due to finite probe-forming aperture size, spatial incoherence, and residual lens aberrations.
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