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Complications and risk factors for severe outcome in children with measles

Andrea Lo Vecchio1, Andrzej Krzysztofiak2, Carlotta Montagnani3

  • 1Department of Translational Medical Sciences - Section of Pediatrics, University of Naples Federico II, Naples, Italy.

Archives of Disease in Childhood
|January 14, 2019
PubMed

Insights

Severe measles outcomes in children are linked to organ complications like pancreatitis and encephalitis, not age or prior conditions. C-reactive protein (CRP) levels can predict severe measles risk.

Area of Science:

  • Pediatric Infectious Diseases
  • Epidemiology

Background:

  • Severe measles outcomes are understudied in high-income nations.
  • Identifying risk factors for severe measles is crucial for timely intervention.

Purpose of the Study:

  • To investigate risk factors for severe measles outcomes in hospitalized children.
  • To define severe outcomes as long-lasting sequelae, intensive care admission, or death.

Main Methods:

  • Retrospective study of 249 children hospitalized for measles across 19 Italian hospitals (Jan 2016 - Aug 2017).
  • Analysis included demographic data, complications, genotypes, and C-reactive protein (CRP) levels.
  • Multivariable analysis identified predictors of severe outcomes.

Main Results:

  • 83% of children developed complications; 1% died.
  • Pancreatitis (aOR 9.19) and encephalitis (aOR 7.02) were significantly associated with severe outcomes.
  • Elevated CRP levels (>2 mg/dL) predicted higher risk of complications (OR 2.0) and severe outcomes (OR 4.13).

Conclusions:

  • Severe measles risk is independent of age and underlying conditions.
  • Organ complications and elevated CRP are key indicators of severe measles.
  • CRP levels can serve as a predictive marker for severe measles outcomes.
Abstract

Keywords:
childrencomplicationgenotypemeaslessevere outcome

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