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Updated: Jan 30, 2026

Murine Full-thickness Skin Transplantation
Published on: January 2, 2017
Clinical efficacy of herbal extract cream on the skin hydration, elasticity, thickness, and dermis density for aged
Seok Seon Roh1, Inhwa Choi2, Hyung-Min Kim3
1Department of Ophthalmology, Otorhinolaryngology &, Dermatology of Korean Medicine, Daejeon University, Daejeon, Korea.
Background:
Traditional medicine herbal prescriptions used for the treatment of skin disease have been developed into cosmetics. Sang-Hyul-Yun-Boo-Em (SHYBE) is a mixed herbal formula prescribed for patients with yin or blood deficiency patterns of skin disease. A previous study reported that SHYBE exercises anti-allergic and anti-inflammatory effects. To date, no study has reported the efficacy of cosmetics containing the SHYBE extract.
Aims:
To observe the efficacy of SHYBE extract cream on hydration, elasticity, thickness, and dermis density in aged skin.
Methods:
This was a double-blind randomized placebo-controlled parallel-group trial. The trial consisted of an 8-week topical application of the test or placebo products with two visits at 4-week intervals. A total of 46 healthy Korean females, aged 40-59, were enrolled in this study. Objective skin assessments for hydration, elasticity, thickness and dermis density, self-assessment, and safety assessment were conducted.
Results:
Sang-Hyul-Yun-Boo-Em extract cream improved skin hydration, elasticity, and dermal density in Asian middle-aged females compared with placebo cream, which excluded SHYBE extract and contained other cosmetic materials.
Conclusions:
Sang-Hyul-Yun-Boo-Em extract cream showed anti-aging properties in middle-aged women. It could be recommended for aging skin with dryness, and loss of elasticity and density.
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