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Updated: Jan 30, 2026

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts
Published on: June 26, 2018
Coumarin-pi, a new antioxidant coumarin derivative from Paxillus involutus
Jin-Xiu Zhang1, Jian-Hua Lv2, Li-Qiang Zhao1
1, Hebei Normal University, Shijiazhuang, PR China.
Abstract:
Chemical investigation of Paxillus involutus lead to the isolation of a new coumarin derivative coumarin-pi (1), and three known compounds (2-4). The structure of the new compound was elucidated by interpretation of 1D and 2D NMR data. Compound 1 possesses a rare benzofuranylcoumarin skeleton. The isolated compounds were evaluated for antioxidant activities and coumarin-pi (1) exhibited significant activity with IC50 value of 16.3 μg/mL.
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