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Related Experiment Video

Updated: Jan 30, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

Abnormalities in P300 components in depression: an ERP-sLORETA study.

Lina Zhou¹, Gaohua Wang¹, Cai Nan¹

¹a Department of Psychiatry , Renmin Hospital of Wuhan University , Wuhan , China.

Nordic Journal of Psychiatry

|January 15, 2019

Summary

Depression is linked to altered brain activity in specific regions. This study found reduced neural activation in the right hemisphere and prefrontal areas in depressed individuals, suggesting their role in the disorder.

Keywords:

Depression P300 event related potential sLORETA source activation

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Published on: April 12, 2018

Area of Science:

Neuroscience
Psychiatry
Cognitive Electrophysiology

Background:

P300 event-related potential alterations are observed in depression.
The specific brain regions underlying these P300 changes in depression are not well understood.

Purpose of the Study:

To investigate the neural activation sources of P300 components in patients with depression.
To identify brain regions associated with depression pathophysiology.

Main Methods:

Used an oddball auditory paradigm to evoke P300 components.
Recorded electroencephalography (EEG) from 30 depressed patients and 30 healthy controls.
Applied standardized Low-Resolution Brain Electromagnetic Tomography (sLORETA) for source localization.

Main Results:

Depressed patients showed lower P200/P300 amplitudes and longer P300 latency compared to controls.
Reduced P200 source activation was found in the right insula, precentral gyrus, and medial/superior/middle frontal gyri.
Decreased P300 source activation occurred in the right insula, postcentral gyrus, superior temporal gyrus, inferior parietal lobule, and prefrontal/cingulate regions.

Conclusions:

Dysfunction in the right hemisphere and bilateral prefrontal cortex may contribute to depression.
These findings highlight specific neural correlates in the pathophysiology of depression.