Related Experiment Video

Updated: Jan 30, 2026

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

1.5K

Targeting the C-MET/HGF Signaling Pathway in Pancreatic Ductal Adenocarcinoma

Sadaf Ghanaatgar-Kasbi1, Shadi Khorrami1, Amir Avan1

  • 1Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Current Pharmaceutical Design
|January 15, 2019
PubMed

Insights

HGF/Met inhibitors show significant anti-tumor activity in pancreatic cancer. These targeted therapies are poised to become essential in managing the disease, offering new hope for patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • The c-mesenchymal-epithelial transition factor (c-MET) signaling pathway is implicated in the development of various cancers.
  • Hepatocyte growth factor (HGF) and its receptor c-MET play critical roles in tumor growth and metastasis.

Purpose of the Study:

  • To review the role of the HGF/Met pathway in pancreatic cancer pathogenesis.
  • To highlight the clinical applications and potential of HGF/Met inhibitors in treating pancreatic cancer.

Main Methods:

  • Literature review of studies focusing on HGF/Met pathway in pancreatic cancer.
  • Analysis of clinical trial data for various HGF/Met inhibitors.

Main Results:

  • HGF/Met pathway is a key driver in pancreatic cancer progression.
  • Several HGF/Met inhibitors, including Cabozantinib, Crizotinib, and Onartuzumab, demonstrate promising anti-tumor activity.

Conclusions:

  • HGF/Met inhibitors represent a significant advancement in pancreatic cancer therapy.
  • These targeted agents are expected to be integral to future cancer management strategies.
Keywords:
HGF/Met inhibitorsanti-tumor activityc-mesenchymal-epithelial transition factorpancreatic cancertumorigenesis.

More Related Videos

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma06:21

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

Published on: November 19, 2019

12.1K
Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

931

Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.6K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.1K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.3K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.4K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
10.6K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
10.0K