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Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
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CUX2 functions as an oncogene in papillary thyroid cancer
Yihan Sun1, Danrong Ye1, Yuefeng Li1
1Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 32500, China, zhangxiaohua1126@163.com.
Oncotargets and Therapy
|January 15, 2019
Summary
CUX2 protein promotes thyroid cancer (TC) development. Silencing CUX2 inhibited tumor growth, migration, and invasion, suggesting CUX2 is a potential therapeutic target for TC.
Area of Science:
- Endocrinology
- Oncology
- Molecular Biology
Background:
- Thyroid cancer (TC) is the most common endocrine malignancy with increasing incidence.
- The CUT/CUX/CDP protein family is implicated in tumor development.
- The role of CUX2 in TC pathogenesis is currently unknown.
Purpose of the Study:
- To investigate the function of CUX2 in thyroid cancer.
- To elucidate the molecular mechanisms underlying CUX2's role in TC.
Main Methods:
- Loss-of-function experiments were performed.
- Western blot analysis was utilized.
- Thyroid cancer cell lines (KTC-1 and BCPAP) were used.
Main Results:
- CUX2 expression was upregulated in papillary thyroid cancer (PTC).
- CUX2 silencing inhibited PTC cell proliferation, colony formation, migration, and invasion.
- CUX2 influenced epithelial-mesenchymal transition (EMT) and the PI3K-AKT-mTOR pathway.
Conclusions:
- CUX2 acts as a tumor promoter in thyroid cancer.
- CUX2 may be a potential therapeutic target for TC.
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