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Vibrio cholerae: Model Organism to Study Bacterial Pathogenesis - Interview
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Growth Inhibitory Effect of Lactocare on Vibrio cholerae

Mahsa Asadi1, Mohamad Reza Fazeli2, Azar Sabokbar1

  • 1Dept of Microbiology, Islamic Azad University, Karaj branch, Karaj, Iran.

Iranian Journal of Pathology
|January 15, 2019
PubMed

Insights

Lactocare, a commercial probiotic, demonstrated significant inhibitory effects against Vibrio cholerae. This suggests its potential in combating diarrheal diseases, particularly in vulnerable populations.

Area of Science:

  • Microbiology
  • Public Health
  • Probiotics

Background:

  • Acute microbial diarrheal diseases pose significant public health challenges, especially in developing nations.
  • Children under five in Asia and Africa are disproportionately affected by waterborne microbial diseases.
  • Limited financial resources and poor hygiene exacerbate the impact of diarrheal diseases.

Purpose of the Study:

  • To investigate the comparative inhibitory effect of Lactocare, a commercial probiotic, on clinical samples and standard strains of Vibrio cholerae.
  • To assess the antimicrobial activity of Lactocare against Vibrio cholerae.

Main Methods:

  • Utilized 20 clinical samples and a standard strain (ATCC 14035) of Vibrio cholerae.
  • Employed biochemical analysis and polymerase chain reaction (PCR) for sample confirmation.
  • Applied the agar well diffusion method to determine the minimum inhibitory concentration (MIC) of Lactocare.

Main Results:

  • Lactocare treatment at 30% concentration inhibited the standard strain of Vibrio cholerae.
  • A 50% concentration of Lactocare led to a significant reduction in colony counts for clinical Vibrio cholerae samples, indicating a move towards the death phase.
  • Higher concentrations of Lactocare are suggested to completely inhibit Vibrio cholerae growth.

Conclusions:

  • Probiotics like Lactocare show promise in developing new pharmaceutical preparations and functional foods.
  • These findings support the potential role of probiotics in promoting public health by controlling microbial diarrheal diseases.
Abstract

Keywords:
Vibrio cholerae;Probiotics; Microbial Sensitivity Tests

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