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Menopause hormone therapy: latest developments and clinical practice.

¹Department of Obstetrics and Gynecology, Faculty Hospital Motol, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.

Drugs in Context

|January 15, 2019

Summary

Menopause hormone therapy (MHT) effectively treats menopausal symptoms and prevents long-term estrogen deficiency. Options include vaginal estrogen, systemic estrogen, tibolone, or nonhormonal treatments like phytoestrogens.

Keywords:

atrophic vaginitis bazedoxifene climacteric syndrome menopause hormone therapy phytoestrogens tibolone

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Area of Science:

Reproductive Endocrinology
Gynecology

Background:

Menopause hormone therapy (MHT) is the primary treatment for acute climacteric syndrome.
Estrogen deficiency during menopause leads to long-term health issues.
Urogenital atrophy requires specific therapeutic approaches.

Purpose of the Study:

To outline efficient therapeutic strategies for menopausal symptom management.
To discuss options for preventing and treating long-term estrogen deficiency.
To review hormonal and nonhormonal treatment modalities for menopausal symptoms.

Main Methods:

Review of current literature on menopause hormone therapy.
Analysis of treatment efficacy for climacteric syndrome and urogenital atrophy.
Comparison of systemic and local estrogen therapies, tibolone, and nonhormonal agents.

Main Results:

Menopause hormone therapy (MHT) is highly effective for acute menopausal symptoms.
Vaginal low-dose estrogen effectively treats urogenital atrophy.
Systemic estrogen and tibolone offer efficient alternatives for systemic treatment.

Conclusions:

Menopause hormone therapy (MHT) provides efficient relief from menopausal symptoms.
Various hormonal and nonhormonal options exist for managing menopause.
Treatment choice depends on symptom profile and patient-specific factors.