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Related Concept Videos

DNA-only Transposons02:57

DNA-only Transposons

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DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
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What is Gene Expression?01:42

What is Gene Expression?

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Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
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What is Gene Expression?01:36

What is Gene Expression?

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A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

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Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
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Related Experiment Video

Updated: Jan 30, 2026

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System
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Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

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Correction to: High-performance gene expression and knockout tools using sleeping beauty transposon system.

Kaishun Hu1, Yu Li1, Wenjing Wu1,2

  • 11Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China.

Mobile DNA
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Summary

This study corrects a previously published article's DOI. The correction ensures accurate citation and retrieval of scientific information for researchers.

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Identification of Sleeping Beauty Transposon Insertions in Solid Tumors using Linker-mediated PCR
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Area of Science:

  • Scientific publishing
  • Bibliometrics
  • Scholarly communication

Background:

  • Accurate citation is crucial for scientific integrity.
  • Digital Object Identifiers (DOIs) are essential for locating research articles.
  • Errors in DOIs can hinder research accessibility and impact.

Purpose of the Study:

  • To correct an erroneous Digital Object Identifier (DOI).
  • To ensure the accurate retrieval of a specific scientific publication.

Main Methods:

  • Identifying the incorrect DOI in the original publication.
  • Verifying the correct DOI through established databases.
  • Issuing a correction notice to the scientific community.

Main Results:

  • The incorrect DOI has been identified and rectified.
  • The corrected DOI is now available for accurate referencing.
  • This ensures the article is discoverable and citable.

Conclusions:

  • Accurate metadata, including DOIs, is vital for the dissemination of research.
  • Correction notices play an important role in maintaining the integrity of the scientific record.
  • Ensuring proper citation practices supports the advancement of science.