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Related Concept Videos

Laminins are the Adhesive Proteins of Basal Lamina00:55

Laminins are the Adhesive Proteins of Basal Lamina

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Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...
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Basal Lamina are the Specialized Form of ECM01:03

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The basal lamina is a thin extracellular layer that lies underneath the cells and separates them from other tissues. The three layers of the basal lamina are lamina lucida, lamina densa and lamina reticularis. The basal lamina, a mixture of glycoproteins and collagen, provides an attachment site for the epithelium, separating it from underlying connective tissue. The framework of basal lamina has other essential proteins such as laminins mesh, perlecan, entactin, and type IV collagen.
Proteins...
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Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

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Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
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What are Cells?01:07

What are Cells?

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Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
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What is Cell Signaling?02:03

What is Cell Signaling?

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
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Concentration Cells02:41

Concentration Cells

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A concentration cell is a type of a  voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
Consider the following voltaic cell:
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Development of Compendium for Esophageal Squamous Cell Carcinoma
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[Terebrant basal cell carcinoma].

Jawad El-Azhari1, Mohammed Boui1

  • 1Service de Dermatologie-Vénérologie, Hôpital d'Instruction Mohammed V, Rabat, Maroc.

The Pan African Medical Journal
|January 15, 2019
PubMed
Summary
This summary is machine-generated.

Basal cell carcinoma (BCC), the most common skin cancer, can become locally invasive and destructive if not diagnosed and surgically treated early. This case highlights a destructive BCC in an elderly patient, emphasizing the need for timely intervention.

Keywords:
Terebrant basal cell carcinomalocal malignancystaging evaluation

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Area of Science:

  • Dermatology
  • Oncology

Background:

  • Basal cell carcinoma (BCC) is the most common type of skin cancer, typically presenting with low metastatic potential.
  • While rarely fatal, untreated BCC can cause significant local tissue destruction and invasion.

Observation:

  • An 80-year-old woman from a rural area presented with a large, ulcerated, exudative, and malodorous lesion in the pretragal and parotid regions.
  • Physical examination revealed no locoregional abnormalities beyond the primary lesion.

Findings:

  • Histopathological analysis confirmed an infiltrative basal cell carcinoma.
  • Staging investigations ruled out bone invasion, indicating a localized but destructive malignancy.

Implications:

  • This case underscores the potential for extensive local invasion and destruction by basal cell carcinoma, even without distant metastasis.
  • Prompt diagnosis and surgical management are crucial to prevent severe tissue damage and disfigurement from basal cell carcinoma.