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Bevacizumab or laser for aggressive posterior retinopathy of prematurity

Michael Blair1,2, Jose Maria Garcia Gonzalez2, Laura Snyder1

  • 1Department of Ophthalmology and Visual Science, University of Chicago, 5841 S. Maryland Avenue, MC2114, Chicago, IL, USA.

Taiwan Journal of Ophthalmology
|January 15, 2019
PubMed

Insights

Aggressive posterior retinopathy of prematurity (APROP) often requires retreatment regardless of initial laser or bevacizumab therapy. Bevacizumab treatment resulted in significantly fewer unfavorable structural outcomes compared to laser treatment for AROP.

Area of Science:

  • Ophthalmology
  • Neonatal care
  • Retinal diseases

Background:

  • Aggressive posterior retinopathy of prematurity (APROP) is a severe condition affecting premature infants.
  • Early detection and treatment are crucial to prevent vision loss.

Purpose of the Study:

  • To compare the reactivation rates and structural outcomes of laser versus bevacizumab treatment for APROP.
  • To evaluate the long-term efficacy of these treatments in managing APROP.

Main Methods:

  • Retrospective chart review of infants diagnosed with APROP.
  • Comparison of treatment outcomes between eyes treated with laser photocoagulation and eyes treated with intravitreal bevacizumab.
  • Inclusion of fluorescein angiography and prophylactic laser for persistent avascular retina.

Main Results:

  • Thirty-six eyes from 19 premature infants were analyzed.
  • Unfavorable structural outcomes were significantly lower in the bevacizumab group (1/22 eyes) compared to the laser group (5/14 eyes; P = 0.002).
  • Reactivation requiring retreatment was common in both groups (9/22 bevacizumab, 6/14 laser).

Conclusions:

  • Reactivation is a common occurrence in APROP, necessitating retreatment irrespective of the initial therapy.
  • Initial bevacizumab treatment is associated with significantly better structural outcomes than initial laser treatment for APROP.
Abstract

Keywords:
Aggressive posterior retinopathy of prematuritybevacizumabretinopathy of prematuritytreatment completion laser

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