Related Experiment Video
Updated: Jan 30, 2026

Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Regulatory T Cells in Gynecologic Cancer
Yang Ou1, Martin J Cannon2, Mayumi Nakagawa1
1Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR USA.
Abstract:
Increasing evidence supports that regulatory T cells (Tregs) within the tumor, tumor draining lymph nodes, ascites and peripheral blood of patients with cancer are associated with poor prognosis. Tregs are important mediators of active immune evasion in cancer. In this review, the potential mechanisms of Treg actions and the roles of Tregs specifically in the tumor microenvironment derived from three types of gynecological cancers, cervical, vulvar and ovarian, are described. The correlations between Tregs and clinical immunotherapeutic study outcomes are discussed. Successful modulation of Tregs would likely have significant impact on the effectiveness of immunotherapeutic treatments in cancer patients.
Related Concept Videos
Cis-regulatory Sequences
Cis-regulatory Sequences
Global Regulatory Systems
Cancer Cell Migration through Invadopodia
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Drug Control Governance: Regulatory Bodies and Their Impact

