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Related Experiment Videos

Lofepramine in the elderly.

B M Pitt1

  • 1St Mary's Hospital, London, England.

International Clinical Psychopharmacology
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

Depression affects 12-13% of older adults, with physical illness a key factor. While lofepramine shows promise for treating elderly depression, more research is needed.

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Area of Science:

  • Geriatric Psychiatry
  • Clinical Psychology

Background:

  • Depression affects 12-13% of the elderly population, with a significant portion experiencing major depressive illness.
  • Admission rates for psychiatric beds in England increase with age, particularly in men, until the 80s.
  • Physical illness is a major contributor to depression in older adults, leading to higher prevalence in hospital inpatients compared to the community.

Purpose of the Study:

  • To highlight the need for improved screening instruments for depression in the elderly.
  • To evaluate the established role and limitations of antidepressant therapy in geriatric depression.
  • To compare the efficacy and safety of dothiepin and lofepramine for treating depression in the elderly.

Main Methods:

  • Review of existing literature on depression in the elderly.

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  • Analysis of psychiatric admission rates by age and gender.
  • Discussion of the side-effect profiles and toxicity indices of commonly used antidepressants.

    • Main Results:

    • Dothiepin, while popular, has a high fatal toxicity index.
    • Lofepramine demonstrates potential for effectiveness with fewer side-effects and improved safety.
    • Limited data exists on lofepramine's use in the elderly, with a need for double-blind comparative studies.

    Conclusions:

    • There is a need for better depression screening tools in the elderly.
    • Lofepramine shows promise as a safer alternative antidepressant for the elderly, especially those with physical illnesses.
    • Further research, including double-blind trials, is required to confirm lofepramine's efficacy and safety in this population.