Related Experiment Video
Updated: Jan 30, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[A recrute with blisters on the cheek]
Maarten W G A Bronkhorst1,2, Albert F Pull Ter Gunne3
1Haaglanden Medisch Centrum, afd. Heelkunde, Den Haag.
Abstract:
A 37-year-old recrute in the Royal Dutch Army developed blisters on the right cheek approximately 30 minutes after a boot camp exercise in the mangroves of the island of Curaçao. This bullous dermatitis was caused by direct contact with sap from the bark of the manzanilla tree (Hippomane mancinella). As a member of the family Euphorbiaceae, all parts of this tree are highly toxic. Even rain drops falling from the leaves can cause a bullous dermatitis. Usually, symptomatic treatment will allow healing of the dermatitis in a matter of weeks.
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