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Oxidative Aminoarylselenation of Maleimides via Copper-Catalyzed Four-Component Cross-Coupling
Xue Gao1, Liyang Tang1, Lehao Huang1
1School of Pharmaceutical Sciences , Wenzhou Medical University , Wenzhou 325035 , People's Republic of China.
Abstract:
The first example of copper-catalyzed four-component coupling reaction of aryl iodides, Se powder, secondary amines, and maleimides is developed. This reaction provides an efficient and concise route to access aminoarylselenated maleimides via double C-Se bonds and C-N bond formation. The appealing features of this transformation are the use of Se powder as a selenating reagent, a green catalytic system, a wide range of substrate scope, and late-stage selenation of bioactive compounds.
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