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Related Experiment Video

Updated: Jan 30, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Circulating Biomarkers Predicting Longitudinal Changes in Left Ventricular Structure and Function in a General

Nicholas Cauwenberghs¹, Susana Ravassa^2,3,4, Lutgarde Thijs¹

¹1 Research Unit Hypertension and Cardiovascular Epidemiology KU Leuven Department of Cardiovascular Sciences University of Leuven Belgium.

Journal of the American Heart Association

|January 15, 2019

Summary

Specific blood biomarkers can predict changes in left ventricular (LV) structure and function over time. These markers, reflecting LV stiffness, injury, and collagen, may help identify individuals at risk for subclinical cardiac issues.

Keywords:

cardiac biomarkers cardiac dysfunction phosphatase population studies remodeling

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Last Updated: Jan 30, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

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Published on: October 28, 2020

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A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Area of Science:

Cardiology
Biomarker Research
Imaging Science

Background:

Serial imaging is crucial for assessing biomarkers predicting left ventricular (LV) remodeling and dysfunction.
This study investigates if baseline circulating biomarkers predict longitudinal changes in LV structure and function in the general population.

Purpose of the Study:

To determine if baseline circulating biomarkers predict long-term changes in LV structure and function.
To identify specific biomarkers associated with adverse cardiac remodeling and dysfunction.

Main Methods:

592 general population participants underwent echocardiography at baseline and after 4.7 years.
Baseline measurements included alkaline phosphatase, collagen turnover markers (procollagen type I, C-terminal telopeptide, matrix metalloproteinase-1), and high-sensitivity cardiac troponin T.
Longitudinal changes in LV indexes were regressed against baseline biomarker levels.

Main Results:

Higher alkaline phosphatase predicted decreased LV longitudinal strain and increased E/e' ratio.
Increased collagen production/degradation markers correlated with reduced LV longitudinal strain.
Elevated high-sensitivity cardiac troponin T predicted increased relative wall thickness and LV mass index.

Conclusions:

A panel of circulating biomarkers can predict adverse changes in LV structure and function.
Biomarkers reflecting LV stiffness, injury, and collagen composition may enhance risk identification for subclinical cardiac maladaptation.