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Related Concept Videos

Lattice Centering and Coordination Number02:33

Lattice Centering and Coordination Number

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The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
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Trends in Lattice Energy: Ion Size and Charge02:54

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An ionic compound is stable because of the electrostatic attraction between its positive and negative ions. The lattice energy of a compound is a measure of the strength of this attraction. The lattice energy (ΔHlattice) of an ionic compound is defined as the energy required to separate one mole of the solid into its component gaseous ions. For the ionic solid sodium chloride, the lattice energy is the enthalpy change of the process:
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Bewley Lattice Diagram01:12

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The Bewley lattice diagram, developed by L. V. Bewley, effectively organizes the reflections occurring during transmission-line transients. It visually represents how voltage waves propagate and reflect within a transmission line, making it easier to understand the complex interactions that occur.
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Structural Joints: Synovial Joints01:16

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Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
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Structural Joints: Fibrous Joints01:03

Structural Joints: Fibrous Joints

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Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
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Structural Joints: Cartilaginous Joints01:17

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As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
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Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture
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Modular Lattice Constructs for Biological Joint Resurfacing.

Kolja Gelse1, Jonas Biggemann2, Martin Stumpf2

  • 11Department of Orthopedic and Trauma Surgery, University Hospital Erlangen, Erlangen, Germany.

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|January 15, 2019
PubMed
Summary
This summary is machine-generated.

Fixing cartilage grafts to bone is challenging. This study introduces a novel modular ceramic lattice with anchoring pins and space for cell-loaded hydrogels, addressing large cartilage defects and osteoarthritis.

Keywords:
3D cell culturecartilagecell adhesionextracellular matrixmodular scaffold

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Area of Science:

  • Biomaterials science
  • Regenerative medicine
  • Orthopedic surgery

Background:

  • Repairing large articular cartilage lesions remains a significant clinical challenge.
  • Graft fixation to the subchondral bone plate is a critical, unresolved issue in cartilage repair.
  • Current treatments often fall short for extensive osteoarthritic defects.

Purpose of the Study:

  • To present a novel modular lattice concept for enhanced cartilage defect repair.
  • To address the limitations of current graft fixation techniques.
  • To bridge the gap between cell therapy and artificial joint replacement.

Main Methods:

  • Development of a modular lattice system using diverse ceramic building blocks.
  • Integration of anchoring pins for secure fixation to the subchondral bone.
  • Incorporation of space for cell-loaded hydrogels or other scaffold materials.

Main Results:

  • The proposed lattice offers a versatile solution for circumscribed cartilage defects and large osteoarthritic lesions.
  • The design facilitates robust graft integration with the subchondral bone.
  • The system accommodates advanced cell-based therapies and biomaterials.

Conclusions:

  • The novel modular ceramic lattice presents a promising approach for complex cartilage repair.
  • This innovation has the potential to significantly impact patient outcomes and reduce healthcare costs.
  • The concept offers a viable alternative to traditional joint arthroplasty for specific indications.