[Disadaptive disorders of regulation of functions at aging.]

This review examines the basic theories of aging, showing the irreversibility of this process, leading to the death of cells and the body. The hypotheses of phenotype and apoptosis discussed, the opinion that disadaptation triggers free radical oxidation reactions and violates the neurohumoral regulation of functions. Briefly examines the mechanisms of development of diseases associated with aging. The hypothesis that partial adaptation and disadaptation is a transitional biological process associated with aging is suggested. A regularity used in the reduction of functional activity (the principle of the limitation of cellular metabolism) is described. In the work, it is shown that aging leads to progression of homeostatic disorders, DNA methylation processes change. The question of the use of antioxidants, endogenous peptides, telomerase, ozone to prevent the negative effects of oxidative stress on biomolecules and cellular structures is considered. An opinion is expressed that the biosynthesis of biogenic amines during disadaptation and aging significantly decreases, which entails a decrease in the regulatory control of biochemical reactions from the hypothalamic-pituitary system. It is proposed to consider biogenic amines and their derivatives as substances that minimize dysregulatory processes that reduce disadaptive manifestations in the body, stimulate cellular metabolism and slow the aging process.