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Updated: Jan 30, 2026
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A High-performance Compact Photoacoustic Tomography System for In Vivo Small-animal Brain Imaging
Published on: June 21, 2017
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Chemical Imaging in Vivo: Photoacoustic-Based 4-Dimensional Chemical Analysis
Chang H Lee1, Jeff Folz2, Joel W Y Tan3
1Department of Chemistry , University of Michigan , Ann Arbor , Michigan 48109 , United States.
Analytical Chemistry
|January 15, 2019
Summary
New nanoagents enable noninvasive, real-time biochemical analysis in vivo. This 4-dimensional imaging provides early tumor chemical information to guide personalized cancer treatment strategies.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Medical Imaging
Background:
- Accurate in vivo biochemical analysis is crucial for effective cancer treatment planning.
- Current imaging techniques may lack the resolution or specificity for early, detailed chemical profiling of tumors.
Purpose of the Study:
- To introduce a novel method for 4-dimensional in vivo biochemical analysis.
- To demonstrate the capability of photoacoustic contrast nanoagents for real-time, spatially resolved chemical imaging.
Main Methods:
- Development of specialized photoacoustic contrast nanoagents.
- Utilizing these nanoagents for 4-dimensional (4D) in vivo imaging.
- Acquiring both structural and chemical information noninvasively.
Main Results:
- Successful implementation of 4D in vivo biochemical analysis.
- Demonstrated ability to probe structural and chemical tumor characteristics in real time.
- Spatially resolved chemical imaging achieved noninvasively.
Conclusions:
- Photoacoustic nanoagents offer a powerful tool for noninvasive, real-time chemical imaging.
- Early chemical imaging of tumors can significantly inform treatment decisions.
- This technology has the potential to optimize choices for chemotherapy, radiation, and immunotherapy.
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