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Related Experiment Video

Updated: Jan 30, 2026

Fabrication of Spatially Confined Complex Oxides

Fabrication of Spatially Confined Complex Oxides

Published on: July 1, 2013

Astrocyte Viability and Functionality in Spatially Confined Microcavitation Zone.

Bo Chen¹, Jessica Tjahja¹, Sameep Malla¹

¹Department of Bioengineering , University of Texas at Arlington , Arlington , Texas 76019 , United States.

ACS Applied Materials & Interfaces

|January 15, 2019

Summary

Blast-induced traumatic brain injury (bTBI) causes microcavitation, damaging brain cells. Researchers found cell damage extends to ~800 μm from microbubble collapse, but poloxamer 188 may offer a potential treatment.

Keywords:

astrocytes blast-induced traumatic brain injury (bTBI)calcium dynamics microcavitation microfabrication poloxamer P188

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Last Updated: Jan 30, 2026

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Preparation of Acute Subventricular Zone Slices for Calcium Imaging

Preparation of Acute Subventricular Zone Slices for Calcium Imaging

Published on: September 19, 2012

Area of Science:

Neuroscience
Biomedical Engineering
Cell Biology

Background:

Blast-induced traumatic brain injury (bTBI) causes significant neurological damage through complex mechanisms.
Microcavitation, the formation and collapse of microscopic bubbles, is a key proposed mechanism in bTBI.
Previous studies showed astrocyte damage from microbubble collapse, but the spatial extent was unclear.

Purpose of the Study:

To precisely determine the spatial extent of astrocyte damage caused by microbubble collapse.
To investigate the impact of microcavitation on astrocyte functionality, specifically calcium signaling.
To evaluate the therapeutic potential of poloxamer 188 (P188) in mitigating bTBI-induced cell damage.

Main Methods:

Utilized microfabrication techniques to spatially control astrocyte seeding relative to microbubble collapse sites.
Monitored real-time calcium spiking activity to assess astrocyte viability and functionality.
Applied poloxamer 188 (P188) to damaged astrocytes to evaluate membrane repair and functional recovery.

Main Results:

Astrocyte functionality, measured by calcium dynamics, was significantly diminished within approximately 800 μm of collapsing microbubbles.
Both trans-membrane calcium influx via N-type channels and intracellular calcium stores were altered by microcavitation.
Poloxamer 188 (P188) successfully reconstituted compromised astrocyte membranes, restoring cellular reparative capabilities.

Conclusions:

Microcavitation-induced damage in bTBI has a defined spatial range affecting astrocyte function.
Calcium signaling pathways are critically disrupted by microcavitation.
Poloxamer 188 shows promise as a therapeutic agent for mitigating bTBI-related cellular damage.