Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions
Christophe D Guillon1, Yi-Hua Jan2, Natalie Foster1
1Department of Chemistry, Lehigh University, Bethlehem, PA 18015 USA.
Bioorganic & Medicinal Chemistry Letters
|January 15, 2019
Abstract:
Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.
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