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Updated: Jan 30, 2026

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
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Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

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Evaluation of Left-Sided Heart Chambers With Novel Echocardiographic Techniques in Men With Duchenne or Becker

Raphael Henrique Déa Cirino1, Rosana Herminia Scola2, Renata Dal-Prá Ducci3

  • 1Cardiology Division, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Parana, Brazil.

The American Journal of Cardiology
|January 15, 2019
PubMed

Insights

Two-dimensional echocardiography effectively evaluates heart structure in Duchenne (DMD) and Becker (BMD) muscular dystrophy patients. Myocardial strain analysis using this method detects early left ventricular systolic dysfunction (LVSD) in a significant number of these patients.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Genetics

Background:

  • Left ventricular systolic dysfunction (LVSD) is prevalent in Duchenne (DMD) and Becker (BMD) muscular dystrophies.
  • Echocardiography is crucial for assessing cardiac function in these patients.

Purpose of the Study:

  • To compare cardiac imaging data from 3D and 2D echocardiography in DMD and BMD patients.
  • To evaluate myocardial strain for early LVSD detection in DMD and BMD.

Main Methods:

  • Cross-sectional study of 46 DMD and 14 BMD patients.
  • Utilized 3D and 2D echocardiography for cardiac measurements.
  • Assessed global longitudinal strain (GLS) via 2D speckle tracking.

Main Results:

  • Strong correlation between 3DE and 2DE for chamber volume measurements.
  • 2DE showed larger chamber volumes, but ejection fraction was similar between techniques.
  • Myocardial strain detected early LVSD in 50% of DMD and 9.1% of BMD patients.

Conclusions:

  • 2D echocardiography is a viable tool for cardiac evaluation in DMD and BMD.
  • Myocardial strain analysis effectively identifies early LVSD in dystrophinopathies.

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