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Ten Secrets to a Long Life.

William H Frishman1

  • 1The Department of Medicine, New York Medical College/Westchester Medical Center, Valhalla.

The American Journal of Medicine
|January 15, 2019
PubMed
Summary

Discover the secrets to a long and healthy life. Research explores factors like genetics, lifestyle, and psychological well-being, with future potential in gene manipulation and senolytic drugs for longevity.

Area of Science:

  • Gerontology and Longevity Research
  • Biomedical Science
  • Public Health

Background:

  • Humanity has long sought to understand the determinants of a long and healthy lifespan.
  • Numerous factors influencing longevity have been identified, encompassing genetics, medical advancements (antibiotics, vaccines), public health initiatives, cardiovascular risk management, surgical progress, behavioral modifications, social support systems, socioeconomic stability, and psychological traits.

Purpose of the Study:

  • To review the multifaceted factors contributing to human longevity and healthy aging.
  • To explore potential future interventions for extending maximum lifespan beyond current estimates.
  • To emphasize the importance of maintaining or enhancing quality of life alongside lifespan extension.

Main Methods:

  • Literature review and synthesis of existing research on aging and longevity.
Keywords:
Life expectancyLife spanLongevityLongevity factorsOld age

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  • Analysis of identified factors contributing to increased lifespan and healthspan.
  • Exploration of emerging scientific concepts and technologies relevant to lifespan extension.

    • Main Results:

    • Longevity is influenced by a complex interplay of genetic, environmental, medical, social, and psychological factors.
    • Current maximum human lifespan is estimated between 115-120 years.
    • Future lifespan extension may involve advanced interventions such as gene manipulation, stem cell therapies, and senolytic drugs.

    Conclusions:

    • Achieving significant increases in maximum lifespan requires further investigation into advanced biological interventions.
    • The pursuit of extended longevity must prioritize the maintenance and enhancement of quality of life.
    • Interdisciplinary approaches combining genetics, medicine, public health, and behavioral science are crucial for advancing healthy aging research.