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Virus deposition onto polyelectrolyte-coated surfaces: A study with bacteriophage MS2
Hien T T Dang1, Volodymyr V Tarabara1
1Department of Civil and Environmental Engineering, 428 South Shaw Lane, Michigan State University, East Lansing, MI 48824, USA.
Journal of Colloid and Interface Science
|January 15, 2019
Summary
Polyelectrolyte multilayers control virus adhesion through surface charge and hydrophilicity. These coatings can regulate virus adsorption and inactivation, reducing human exposure.
Area of Science:
- Materials Science
- Surface Chemistry
- Biophysics
Background:
- Polyelectrolyte multilayers (PEMs) offer tunable surface properties.
- Controlling virus adhesion is crucial for public health and biosensing.
- Understanding virus-surface interactions informs material design.
Purpose of the Study:
- To design PEMs with controlled virus adhesion properties.
- To investigate the role of charge and hydrophilicity in virus adsorption.
- To evaluate PEMs as antiviral coatings.
Main Methods:
- Layer-by-layer assembly of charged polyelectrolytes (poly(styrene-4-sulfonate) and poly(dimethyl diallyl ammonium chloride)).
- Contact angle measurements to assess MS2 hydrophilicity.
- Quartz crystal microbalance with dissipation monitoring to study MS2 adhesion.
- Extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) theory for interaction analysis.
Main Results:
- Virus deposition occurred in two phases: virus-surface and virus-virus interactions.
- Deposition rates correlated with the secondary minimum of the XDLVO energy profile.
- Hydrophobic and electrostatic interactions governed deposition; hydrophilic repulsion prevented primary minimum adhesion.
- PEMs exhibited distinct MS2 deposition kinetics and capacities.
Conclusions:
- PEMs can be engineered to control virus adsorption.
- Surface properties like charge and hydrophilicity are key determinants of virus adhesion.
- PEMs show potential as antiviral coatings for inactivation and exposure reduction.
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