Drug Carrier-Oriented Polygeline for Preparing Novel Polygeline-Bound Paclitaxel Nanoparticles

Area of Science:

• Pharmaceutical Sciences
• Materials Science
• Nanotechnology

Background:

• Polygeline, a low-cost albumin-like material, shows potential as a drug carrier.
• Paclitaxel (PTX) is a crucial chemotherapeutic agent with limitations in delivery.
• Nanoparticle formulations are vital for improving drug efficacy and reducing side effects.

Purpose of the Study:

• To fabricate polygeline-bound paclitaxel nanoparticles (Npb-PTXS).
• To optimize production parameters for Npb-PTXS.
• To characterize Npb-PTXS and evaluate its in vivo performance.

Main Methods:

• Fabrication via low-pressure emulsification and high-pressure homogenization.
• Systematic evaluation of production parameters (pH, protein concentration, PTX ratio, pressure, passes).
• Characterization of particle size, morphology, drug loading, encapsulation efficiency, redispersibility, and in vivo bioavailability.

Main Results:

• Optimal conditions yielded Npb-PTXS with mean particle size of 188.3 nm, PDI of 0.163, and zeta potential of -31.1 mV.
• Amorphous paclitaxel encapsulation efficiency reached 81.2%.
• Npb-PTXS demonstrated good resolubility and an in vivo relative bioavailability of 83.89% compared to Abraxane.

Conclusions:

• Polygeline-bound paclitaxel nanoparticles (Npb-PTXS) were successfully fabricated.
• Optimized Npb-PTXS exhibit favorable physicochemical properties and good in vivo performance.
• Npb-PTXS represent a promising nanocarrier for paclitaxel delivery.