Serum beta 2-microglobulin after five-day administration of cisplatin

Patients with testicular tumors receiving the Einhorn combination chemotherapy with cisplatinum administration for five consecutive days were evaluated for signs of glomerular filtration rate impairment by means of serum beta 2-microglobulin measurements before and on days 2 and 5 after cessation of cisplatin administration and then before repeated cycles of the same chemotherapeutic regimen. Though no significant changes in the level of serum beta 2-microglobulin could be found, an evident increase in the values was seen indicating that in more aggressive cisplatin administration schedules not only tubular impairment might contribute to possible nephrotoxic effects.