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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

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Covalently Linked Protein Regulators02:04

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
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Covalently Linked Protein Regulators02:04

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X-linked Traits01:19

X-linked Traits

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In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
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Sex-linked Disorders01:43

Sex-linked Disorders

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Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
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Related Experiment Video

Updated: Jan 30, 2026

Orthotopic Mouse Model of Colorectal Cancer
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Colorectal cancer: the APC-lncRNA link.

Pat J Morin

    The Journal of Clinical Investigation
    |January 15, 2019
    PubMed
    Summary

    The adenomatous polyposis coli (APC) gene regulates cell growth by controlling Wnt signaling. A new study reveals APC influences a novel long noncoding RNA, impacting exosome production and cancer progression.

    Area of Science:

    • Molecular Biology
    • Cancer Biology
    • Genetics

    Background:

    • The adenomatous polyposis coli (APC) gene is critical for regulating cell proliferation and survival.
    • APC's known function involves the canonical Wnt signaling pathway.

    Purpose of the Study:

    • To elucidate a novel mechanism of APC function.
    • To investigate the role of APC in regulating long noncoding RNA (lncRNA) and exosome production.
    • To explore the clinical significance of this pathway in APC-mutated cancers.

    Main Methods:

    • Investigated the interaction between APC and a novel lncRNA.
    • Assessed the impact of APC signaling on exosome production.
    • Analyzed the effects on cell proliferation, invasion, and angiogenesis.

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    Related Experiment Videos

    Last Updated: Jan 30, 2026

    Orthotopic Mouse Model of Colorectal Cancer
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    A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
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    Main Results:

    • Identified a new pathway where APC regulates a novel lncRNA.
    • Demonstrated that this APC-lncRNA pathway modulates exosome production.
    • Showed this mechanism influences cancer cell proliferation, invasion, and angiogenesis.

    Conclusions:

    • APC exerts novel functions through lncRNA regulation, impacting exosome production.
    • This pathway offers new insights into APC's role in cancer.
    • The findings suggest potential therapeutic targets for APC-mutated cancers.