Related Experiment Video

Updated: Jan 30, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

735

C-reactive protein and blood pressure variability in type 2 hypertensive diabetic patients

Andressa S O Schein1,2, Patrícia M Bock3,4, Daniela Massierer1

  • 1Cardiology and Endocrine Divisions.

Blood Pressure Monitoring
|January 15, 2019
PubMed

Insights

In patients with type 2 diabetes and hypertension, high C-reactive protein (CRP) levels correlate with other cardiometabolic issues. However, elevated CRP was not linked to increased blood pressure (BP) variability in this study.

Area of Science:

  • Cardiology
  • Endocrinology
  • Clinical Research

Background:

  • Blood pressure (BP) variability and inflammation are recognized predictors of cardiovascular events in patients with type 2 diabetes and hypertension.
  • C-reactive protein (CRP) is a marker of inflammation and a potential predictor of cardiovascular risk.

Purpose of the Study:

  • To investigate the association between C-reactive protein (CRP) levels and blood pressure (BP) variability in patients diagnosed with both type 2 diabetes and hypertension.

Main Methods:

  • A cross-sectional study was conducted with 285 patients who had type 2 diabetes and hypertension.
  • Evaluated laboratory characteristics and performed 24-hour ambulatory BP monitoring.
  • Assessed BP variability using standard deviation (SD), coefficient of variation (CV%), and time-rate index; patients were grouped by CRP levels (low vs. high).

Main Results:

  • Patients with high CRP levels exhibited increased office systolic and diastolic BP.
  • No significant differences in BP variability indexes (SD, CV%, time rate) were observed between low and high CRP groups.
  • Higher BMI, total cholesterol, and HbA1c levels were noted in the high CRP group.

Conclusions:

  • In diabetic-hypertensive patients, elevated CRP levels are associated with cardiometabolic derangements.
  • Higher CRP levels were not found to be associated with increased blood pressure variability in this patient cohort.
Abstract

More Related Videos

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

1.0K
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K

Related Concept Videos

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.2K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.9K
Fluid Pressure over Flat Plate of Variable Width01:02

Fluid Pressure over Flat Plate of Variable Width

When a flat plate is submerged in a fluid, the fluid exerts pressure on the plate. This pressure can lead to many different phenomena, including drag and buoyancy. To understand the behavior of the fluid over a flat plate of variable width, it is essential to analyze the distribution of the pressure exerted.
The pressure distribution on the plate can be calculated by determining the force that acts on a differential area strip of the plate. Thus, the magnitude of the force is equal to the...
2.1K
Blood Pressure01:24

Blood Pressure

The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
10.1K
Blood Pressure01:30

Blood Pressure

Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
4.4K
Blood Typing01:10

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
2.8K