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Updated: Jan 30, 2026
08:25
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
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Atopy and Sensitization to Allergens Known to Cause Systemic Contact Dermatitis.
Jeffrey F Scott, Rosalynn R Z Conic, InYoung Kim
1Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH.
Dermatitis : Contact, Atopic, Occupational, Drug
|January 15, 2019
Summary
Children and adolescents with atopic dermatitis (AD) and respiratory atopy show higher rates of positive patch tests to systemic contact dermatitis (SCD) allergens. Wet work occupations are also linked to increased sensitization in AD patients with respiratory atopy.
Area of Science:
- Dermatology
- Allergology
- Immunology
Background:
- Atopic dermatitis (AD) with respiratory involvement may indicate systemic contact dermatitis (SCD).
- AD flares can be triggered by ingested or inhaled allergens in susceptible individuals.
Purpose of the Study:
- To compare the frequency of positive patch tests to known SCD allergens.
- To evaluate these in AD patients with and without respiratory atopy.
Main Methods:
- Retrospective analysis of AD patients undergoing patch testing.
- Tested allergens included 23 known to cause SCD.
- Results stratified by age and occupation (wet vs. dry work).
Main Results:
- Children and adolescents with AD and respiratory atopy had significantly higher positive patch test rates (OR 2.33).
- Adults did not show this increased likelihood.
- AD patients with respiratory atopy in wet work occupations were more likely to have positive tests (OR 1.47).
Conclusions:
- Respiratory atopy is associated with sensitization to SCD allergens in AD patients, particularly in younger individuals.
- Wet work occupations exacerbate this association.
- Patch testing can identify systemic triggers for dermatitis in AD patients.
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