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Fecal Fat Concentration and Excretion in the First 2 Years of Life: a Cross-Sectional Study

Mirosława Wieczorek-Filipiak1, Sławomira Drzymała-Czyż1, Mariusz Szczepanik1

  • 1Department of Pediatric Gastroenterology and Metabolic Diseases.

Journal of Pediatric Gastroenterology and Nutrition
|January 15, 2019
PubMed

Insights

Healthy infants and toddlers up to 2 years old often have higher fecal fat concentration (FFC) and fecal fat excretion (FFE) than older children. This study establishes new reference values for these key indicators in young children.

Area of Science:

  • Pediatric Gastroenterology
  • Nutritional Science
  • Clinical Biochemistry

Background:

  • Pancreatic exocrine secretion data in infants and toddlers is limited.
  • Establishing normal ranges for fecal fat concentration (FFC) and fecal fat excretion (FFE) is crucial for diagnosing conditions in young children.

Purpose of the Study:

  • To determine the normal range of FFC and FFE in infants and toddlers up to 2 years of age.
  • To create a detailed nomogram for assessing FFC and FFE in this age group.

Main Methods:

  • 160 subjects aged 1 to 24 months were divided into 8 age groups.
  • Fecal fat concentration (FFC) and fecal fat excretion (FFE) were measured using 3-day stool collections.

Main Results:

  • FFC significantly correlated with age (r = -0.50, P < 0.0001).
  • 65% of infants aged 1-3 months had FFC above the 5% norm for older children.
  • FFE did not vary by age group but was higher than established norms in a significant percentage of infants.

Conclusions:

  • Healthy infants and toddlers can exhibit higher FFC and FFE compared to older children.
  • The study provides essential reference values for accurate interpretation of FFC and FFE in clinical practice.
  • A nomogram was developed to aid in the precise assessment of pancreatic exocrine function in young children.
Abstract

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